Overweight children with type 2 sibling more at risk to develop blood glucose abnormality

Philadelphia researchers find overweight siblings of children with type 2 diabetes are more likely to have abnormal glucose levels compared to other overweight children. Researchers from The Children’s Hospital of Philadelphia published their findings December 9 in the online edition of the Journal of Pediatrics.

The study looked at 62 children: 20 obese subjects with a sibling who had type 2 diabetes and a control group of 42 obese children.The researchers found that overweight siblings of children with type 2 diabetes had four times greater odds of having abnormal glucose levels (impaired glucose tolerance or type 2 diabetes) than other overweight children. However, investigators found no significant differences in insulin resistance, as measured by the homeostasis model assessment.

The researchers also add that identifying groups at high risk for type 2 diabetes during childhood, such as obese siblings of children with type 2 diabetes, could help guide screening of obese children for abnormal glucose tolerance by primary care providers. This could also help to identify children who might benefit from participation in future type 2 diabetes prevention studies.

The research was supported by grants from the National Institutes of Health and the National Center for Research Resources.

Source: Science Daily

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