New weapon to fight diabetes with red wine substance

GSK company, and its research study team claimed to have discovered a new chemical entity that protects against diet-induced obesity. It also improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

After one year research, the researchers have used the resveratrol, a substance naturally occurring in red wine. Researchers hypothesized that these beneficial effects result from activation of SIRT1, an enzyme that is involved in regulating certain key cellular processes, notably the efficiency and number of mitochondria – the energy powerhouses of our cells. Because dietary management and exercise rarely succeed by themselves in curbing obesity and associated metabolic disorders, interest has increased in using the SIRT1 pathway as a target for possible pharmacological intervention.

To assess the new SIRT1 activator on metabolic function, mice were fed a high-fat diet over a period of 15 weeks, while receiving average drug exposures of 100 to 500 mg/kg/day. Mice on a high-fat diet treated with the higher drug dose did not become obese, and their triglyceride, cholesterol, fasting blood glucose and insulin levels were all reduced. Furthermore, they were able to run approximately twice the distance as control animals in an endurance exercise test.

The study was published in the November 5 issue in the journal Cell Metabolism.

Source: The Hindu

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