In order to assess the genetic similarities and differences between the type 1 diabetes and celiac disease, researchers obtained 8,064 samples from people with type 1 diabetes, 2,560 samples from individuals with celiac disease and 9,339 control samples.
Researchers have identified seven chromosome regions that are shared between type 1 diabetes and celiac disease.
According to Richard M. Plenge, MD, PhD, a rheumatologist at Brigham and Women’s Hospital in Boston,
New findings provide an answer the families who seem to have an undue susceptibility to two autoimmune diseases: type 1 diabetes and celiac disease.
These findings also suggest that type 1 diabetes and celiac disease may be caused by uncommon underlying mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens.
The researchers believe that these regions of the chromosomes regulate the mechanisms that cause the immune system to attack both pancreatic beta cells and the small intestine.
Researchers also believes that the two autoimmune diseases not only share genetic causes but similar environmental triggers as well.
The study also support further evaluation of the hypothesis that cereal and gluten consumption might be an environmental factor in type 1 diabetes, related to gut and pancreatic immune system.
Source: Endocrine today