Same Protein Linked To Diabetes & Atherosclerosis同樣的蛋白質有聯繫的糖尿病與動脈粥樣硬化
Called aP2, a protein that has no useful function in the body, is not only responsible for type 2 diabetes and atherosclerosis, may also be responsible for asthma by regulating inflammation in human lung a new research says.所謂ap2 ，蛋白質沒有有用的功能，在身體，不僅是負責任的2型糖尿病和動脈粥樣硬化，也可能是負責規管哮喘炎症的人肺一項新的研究說。
To study the effects of aP2, the researchers created genetically engineered mice that could not produce the protein.的影響進行研究ap2 ，研究人員創造了遺傳工程小鼠未能出示的蛋白質。 Researchers cannot make them obese, diabetic or atherosclerotic.研究人員不能使它們肥胖，糖尿病或動脈粥樣硬化。 They don’t develop fatty liver disease, and they don’t develop asthma.他們不發展脂肪性肝病，他們不發展哮喘。
Human trials of aP2-blocking drugs probably won’t be held for another three or four years, said study co-author Dr. Gokhan S. Hotamisligil, of the Harvard School of Public Health in Boston.人體試驗的ap2阻斷藥物可能不會舉行另外三或四年，說，研究的共同作者，博士gokhan第霍塔米甚利吉爾，哈佛公共衛生學院在波士頓。 Meanwhile, he and his colleagues are investigating lifestyle interventions that may help reduce aP2 levels.與此同時，他和他的同事現正調查生活方式的干預，可能有助於減少ap2的水平。 For clues, they’re studying human subjects who carry a rare genetic mutation that makes them produce 50 percent to 60 percent less aP2 than normal.為線索，他們正在研究以人為對象的誰進行一種罕見的基因突變，使他們產生50 ％至60 ％以下ap2較正常。 Results of the study could be published within a year, Hotamisligil said.研究的結果可以公佈1年，霍塔米甚利吉爾說。
For now, he said, weight control may be the best strategy for countering the ill effects of aP2.現在，他說，控制體重可能是最好的策略，對付的後遺症ap2 。 “The most important implication of this research is that it demonstrates a direct link between the pathways that lead to obesity and diabetes and asthma,” he said. “最重要的意義本研究的是，它表明之間的直接聯繫的途徑，導致肥胖與糖尿病和哮喘的， ”他說。 “aP2 tends to go along with your weight and the state of your glucose metabolism. “ ap2往往去，隨著你的體重和國家您的葡萄糖代謝。 So, if you’re overweight and have asthma, losing weight might help your asthma.”因此，如果您是超重和有哮喘，減重可能幫助您的哮喘“ 。
A growing body of research suggests that the obesity and asthma epidemics are related.越來越多的研究表明，肥胖與哮喘的流行是相關的。 In March, researchers from the University of New Mexico School of Medicine published research showing an increased risk of asthma in overweight women whose fat cells produce high levels of a hormone called leptin.在3月，研究人員從新墨西哥大學醫學院發表的研究顯示的風險增加了哮喘的超重婦女，其脂肪細胞產生高水平的荷爾蒙稱為瘦素。
Filed under提起下 Diabetes糖尿病 | |
