According to a study over 124 children with type 1 diabetes, high-dose folate and vitamin B6 can normalize endothelial function, a precursor of vascular disease, which begins early in juvenile diabetes.
In the research, 124 children with type 1 diabetes was treated with folate (5 mg/d) and vitamin B6 (100 mg/d) for eight weeks.
Endothelial function, assessed as flow-mediated dilation and glyceryltrinitrate-induced dilation with high-resolution ultrasound of the brachial artery, was measured at baseline, at 2 and 4 hours after the first dose (n = 35), and at 4 and 8 weeks of treatment (n = 122). From baseline to 8 weeks, flow-mediated dilation improved with folate from 2.6% +/- 4.3% (mean +/- SD) to 9.7% +/- 6.0%, with vitamin B6 from 3.5% +/- 4.0% to 8.3% +/- 4.2%, and with folate/vitamin B6 from 2.8% +/- 3.5% to 10.5% +/- 4.4%.
The researchers concluded high-dose folate and vitamin B6 normalized endothelial dysfunction in children with type 1 diabetes; and this effect was maintained over 8 weeks, with no additional benefit from combination treatment.
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