Diabetes Drugs May Lead To Bone Fracture
Thiazolidinediones, a widely used class of diabetes drugs can lead to bone fracture risk. Recent study in Switzerland proves that Pioglitazone and rosiglitazone, widely used drugs of the class, can lead to problems like slower bone formation and faster bone loss. It can be mentioned that both of two drugs account for 21 percent of oral diabetes medications prescribed in the United States and 5 percent of those in Europe respectively.
Christian Meier, M.D., of University Hospital Basel, Basel, Switzerland, and colleagues studied 1,020 patients with diabetes who had fractures, diagnosed at British general practitioners’ offices between 1994 and 2005. For each of those patients, up to four control patients with diabetes were selected for a total of 3,728 matched controls. They had the same age and sex and also had the same physician. But they never came across any fracture.
The study clearly indicates that patients taking Pioglitazone and rosiglitazone, run approximately double the chances of hip and other non-spine fractures than those who did not take these. Thus the analysis provides further evidence of a possible association between long-term use of thiazolidinediones and fractures, particularly of the hip and wrist, in patients with diabetes mellitus.
Source: Science Daily
Filed under Diabetes, Diabetes Drug
